Resveratrol Side Effects, Interactions and Who Should Avoid It
Resveratrol is generally well tolerated, but it isn't right for everyone. Here's what the research says about side effects and drug interactions.
The big picture
Across 194 human studies reviewed in 2024, resveratrol was generally well tolerated at doses up to about 1 gram per day. Side effects were reported mainly at much higher doses. Still, "well tolerated" doesn't mean "right for everyone" — interactions with medications are the most important thing to check.
Possible side effects
Digestive upset
The most commonly reported side effects are nausea, gas, abdominal discomfort and diarrhea — mostly at doses of 2.5–5 g per day. For context, one SelfPlus AGE+ capsule is 125 mg. If you have a sensitive stomach, taking your capsule with food may help. Japanese knotweed extracts can also contain small amounts of emodin, which has a laxative effect at higher amounts.
Headache, dizziness or rash
Occasionally reported. Stop taking it and talk to a healthcare professional if these persist.
Effects at very high doses
Some high-dose studies in sick populations reported changes in liver or kidney markers. That isn't expected at supplement doses like 125 mg, but it's one reason not to exceed the label.
Drug interactions — the key safety issue
| Medication type | Possible interaction | What to do |
|---|---|---|
| Blood thinners and antiplatelets (warfarin, clopidogrel, aspirin, etc.) | Resveratrol may slow clotting and increase bleeding risk | Ask your doctor before use |
| Drugs processed by CYP3A4 / CYP2C9 liver enzymes | May change drug levels in the blood | Have your pharmacist check your list |
| Diabetes medication | Possible additive effect on blood glucose | Monitor and discuss with your doctor |
| Blood pressure medication | Possible additive effect | Discuss with your doctor |
| Hormone therapy / hormone-sensitive conditions | Weak estrogen-like activity in some studies | Ask your doctor first |
Cleared by your doctor? SelfPlus AGE+ keeps the dose moderate at 125 mg.
Check Availability →Who should avoid or check first
- Pregnant or breastfeeding women — not enough safety data.
- Anyone scheduled for surgery — many clinicians suggest stopping about two weeks before.
- People with bleeding disorders.
- People with hormone-sensitive conditions.
- Children and teenagers under 18.
- Anyone allergic to Japanese knotweed or other ingredients in the product.
How to reduce your risk
- Show the product label to your doctor or pharmacist.
- Stick to one capsule a day and don't stack several resveratrol products.
- Start with a single bottle if you're unsure how you'll respond.
- Stop and seek advice if you notice unusual bruising, bleeding or ongoing stomach upset.
- Buy from the official store so you know what's in the bottle.
What about SelfPlus AGE+ specifically?
SelfPlus AGE+ contains 125 mg of trans-resveratrol per capsule — a moderate dose well below the levels where side effects become common in studies. The same interaction cautions apply as with any resveratrol supplement. SelfPlus itself advises consulting your physician if you're pregnant, nursing, taking medication or have a medical condition. See our safety and quality page for more.
Where SelfPlus AGE+ fits
SelfPlus AGE+ provides 125 mg of trans-resveratrol from Japanese knotweed root (250 mg extract, 50% standardized) in one daily capsule, from $54 per bottle with a 60-day money-back guarantee. See the full label · See prices
Sources: Brown K, et al. “Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials.” Int J Mol Sci 2024;25(2):747. General drug-interaction information from NIH resveratrol resources. This page is general information, not medical advice.
Quick questions
Can resveratrol affect my liver?
Liver-marker changes have mainly been reported in high-dose studies in people who were already ill. At moderate supplement doses this isn't expected, but talk to your doctor if you have liver disease or take medicines processed by the liver.
Is resveratrol safe to take long term?
Trials have lasted up to a year or more without major safety concerns at moderate doses. Long-term use should still be reviewed with your healthcare provider, especially if your medications change.
What should I do if I notice a side effect from SelfPlus AGE+?
Stop taking it and contact your doctor. If it's not right for you, you can also use the 60-day money-back guarantee.
Ready to try SelfPlus AGE+?
Order from the official SelfPlus store and you're covered by the 60-day money-back guarantee.
Check Availability →One capsule a day · 125 mg trans-resveratrol · From $54/bottle